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讲准字178号:虫媒病毒生命周期的故事:从宿主到蚊子的捕获机理

发布时间:2019-06-15|浏览次数:

讲座报告主题:虫媒病毒生命周期的故事:从宿主到蚊子的捕获机理
专家姓名:程功
日期:2019-06-21 时间:08:40
地点:会议中心第一报告厅
主办单位:生命科学研究院  

主讲简介:清华大学医学院基础医学系研究员、博导,曾荣获国家杰出青年科学基金、药明康德生命化学研究奖、谈家桢生命科学创新奖、中源协和生命医学创新突破奖、树兰医学青年奖、Grand Challenge青年科学家、牛顿高级学者。研究专长:研究方向为虫媒病毒性传染病的致病机理及疫苗研发,研究主要涉及登革热病毒、乙型炎病毒、基孔肯亚热等蚊媒病毒在哺乳动物宿主及节肢动物媒介中的感染机制。

主讲内容:Arboviruses naturally circulate between vertebrate hosts and an arthropod vectors. Viral acquisition from an infected mammalian host by a vector is one of essential steps in their lifecycles. However, little information is available regarding the molecular mechanisms underlying the viral acquisition by arthropod vectors. Here, we will introduce multiple mechanisms in mosquito-borne viral acquisition, including: 1) A gut commensal bacteria promote mosquito susceptibility to arboviruses by blood meal; 2) Nonstructural protein-1 (NS1), which is abundantly secreted into the serum of an infected host, is a key factor for flavivirus acquisition from infected hosts to fed mosquitoes; 3) the hematophagous nature of mosquitoes contributes to arboviral acquisition after a blood meal, via suppressing antiviral innate immunity by activating the GABAergic pathway. Altogether, our studies demonstrate that arboviruses smartly utilize multiple materials, either produced in their vertebrate phases or existing in vectors, to enhance their acquisition by vectors, therefore facilitating arbovirus survival in nature.


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