讲座报告主题：Cellular toxicity of nanoparticles/ Measurement of mycotoxin exposure in human populations using biomarkers of exposure
专家姓名：Michael Norman Routledge
主讲简介：Michael Norman Routledge，1991年毕业于约克大学，获环境致癌作用专业博士学位，长期从事食品卫生的教学和科研工作，研究方向主要为食品霉菌毒素的安全性评价和人群预防措施。科研工作主要着眼于食品化学污染物的暴露测量和人体健康效应评价。作为学科领域的学术带头人，先后承担国际研究项目12项，在国际该领域杂志上发表论文近80篇，参与著书7册。研究工作被许多国际权威机构引用论证真菌毒素的健康风险。其科研工作得到英国皇家学会、英国政府、比尔盖茨基金会等的大力资助。研究专长：食品毒理学。
主讲内容：“Cellular toxicity of nanoparticles”：Engineered nanoparticles are used in many food products and can also enter the environment, leading to potential exposure through ingestion, inhalation or absorption. As part of a European collaboration called ENNSATOX, SiO2, TiO2 and ZnO nanoparticles of varying size and morphology were tested for toxicity. In this seminar the results of toxicity and genotoxicity tests on cultured colon, skin and lung cells will be described. In addition to comparing size and shape on toxicity, the mechanism of cellular uptake of silica nanoparticles was determined using electron microscopy. Nano and ultrafine particles are also produced during combustion, and are key components of air pollution in urban environments. Evidence of the increased toxicity of ultrafine particulate matter collected at the roadside on lung cells, and the impact of these particulates on vascular endothelial cells will also be presented. “Measurement of mycotoxin exposure in human populations using biomarkers of exposure”：There are a number of mycotoxins that have potential to impact on human health, including aflatoxin, fumonisins and deoxynivalenol. Of these, aflatoxin is the most potent and is known to cause acute illness as well as be carcinogenic. We have used biomarkers to assess individual exposure to these toxins in order to assess their potential health effects in epidemiological studies. In this seminar, the biomarker methods will be described, as well as data being presented from studies in African populations, where the impact of mycotoxin exposure is high.